Dihydropyridine calcium channel blockers and peripheral side effects
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چکیده
منابع مشابه
Dihydropyridine Calcium Channel Blockers
T he concept of proarrhythmia, the realization that antiarrhythmic drugs can occasionally drastically aggravate the very problem for which they were prescribed, is now widely appreciated and has undoubtedly lead to an overall improvement in the use of these drugs. Proarrhythmia is a particularly dangerous type of side effect: It is unpredictable, may easily escape detection, and can turn a beni...
متن کاملSide effects of calcium channel blockers.
Calcium channel blocking drugs are a chemically heterogenous group, so it might be expected that their effects on vascular smooth muscle, cardiac contractility, and conduction tissue may differ. However, the majority of adverse reactions are predictable from their pharmacological actions and may be conveniently grouped in the following categories: 1) vasodilatation, 2) negative inotropic effect...
متن کاملDihydropyridine Calcium- Channel Blockers for Antihypertensive Treatment
Subjects. Patients aged :<:: 60 years with sitting systolic blood pressure (BP) 160 219 mmHg and sitting diastolic BP< 95 mmHg during run-in phase. Methods and Results. Four thousand, six hundred and ninety-five patients were randomly assigned to active treatment (N = 2 398), i.e. nitrendipine, with the possible addition of enalapril and hydrochlorothiazide, or to matching placebos (N = 2 297)....
متن کاملPleiotropic Effects of Calcium Channel Blockers
Clinical trials have reported reduced cardiovascular events with certain antihypertensive agents at a rate that could not be predicted by changes in brachial arterial pressure alone. These findings may be explained, in part, by pleiotropic effects of these agents and modulation of central blood pressures. This review focuses on the mechanisms by which calcium channel blockers exert pleiotropic ...
متن کاملThe role of calcium channel blockers in wound healing
Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2001
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1001248